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Conjunctival Melanoma A 38-year-old healthy man presents with a pigmented lesion two years after onset and undergoes excisional biopsy which confirms conjunctival melanoma. Systemic work-up reveals metastasis, and the patient undergoes multiple cycles of radiation and chemotherapy. He later died of…

Retained Lens Fragment A 61-year-old male referred after complicated cataract extraction surgery (phacoemulsification). On exam he was found to have a large piece of retained nuclear fragment in the inferior vitreous. He underwent PPV along with lens exchange with anterior chamber IOL placement. He…

Retained Lens Fragment A 61-year-old male referred after complicated cataract extraction surgery (phacoemulsification). On exam he was found to have a large piece of retained nuclear fragment in the inferior vitreous. He underwent PPV along with lens exchange with anterior chamber IOL placement. He…

Normal Tension Glaucoma A 22-year-old previously healthy female from Guatemala presents as a referral for “severe glaucoma” with symptoms of intermittent headaches and gradual decline in vision most notable in the left eye. On exam the patient is found to have low-normal intraocular tension, op…

Normal Tension Glaucoma A 22-year-old previously healthy female from Guatemala presents as a referral for “severe glaucoma” with symptoms of intermittent headaches and gradual decline in vision most notable in the left eye. On exam the patient is found to have low-normal intraocular tension, op…

Primary Vitreoretinal Lymphoma A 77-year-old female with a history of vitritis of unknown origin and two non-diagnostic vitrectomies presented with a white plaque on the posterior capsule of her left eye after being lost to follow up for several years. Repeat vitrectomy confirmed the suspected diag…

Primary Vitreoretinal Lymphoma A 77-year-old female with a history of vitritis of unknown origin and two non-diagnostic vitrectomies presented with a white plaque on the posterior capsule of her left eye after being lost to follow up for several years. Repeat vitrectomy confirmed the suspected diag…

Fungal Keratitis A 59-year-old female presented to the Bascom Palmer Eye Institute emergency room with a 7-day history of a red and painful eye, and loss of vision. The right eye exam demonstrated HM vision with a diffuse limbal-to-limbal cornea ulcer within a previous penetrating keratoplasty graf…

Fungal Keratitis A 59-year-old female presented to the Bascom Palmer Eye Institute emergency room with a 7-day history of a red and painful eye, and loss of vision. The right eye exam demonstrated HM vision with a diffuse limbal-to-limbal cornea ulcer within a previous penetrating keratoplasty graf…

Ocular Cicatricial Pemphigoid An 83-year-old monocular male presented to the Cornea division, Bascom Palmer Eye Institute with bilateral decreased vision, pain redness and burning for many years getting progressively worse. Examination revealed hand motion vision, ankyloblepharon and chronic cicatr…

Ocular Cicatricial Pemphigoid An 83-year-old monocular male presented to the Cornea division, Bascom Palmer Eye Institute with bilateral decreased vision, pain redness and burning for many years getting progressively worse. Examination revealed hand motion vision, ankyloblepharon and chronic cicatr…

Autosomal Recessive RPE65-Deficient Leber Congenital Amaurosis A 17-year-old male with a biallelic RPE65 mutation resulting in autosomal recessive Leber Congenital Amaurosis is referred for evaluation for subretinal gene therapy with voretigene neparvovec-rzyl. Baseline evaluation was remarkable fo…

Autosomal Recessive RPE65-Deficient Leber Congenital Amaurosis A 17-year-old male with a biallelic RPE65 mutation resulting in autosomal recessive Leber Congenital Amaurosis is referred for evaluation for subretinal gene therapy with voretigene neparvovec-rzyl. Baseline evaluation was remarkable fo…

Extranodal Rosai-Dorfman Disease A 28-year-old male without past medical history presented with a 1 year history of painless bilateral upper lid swelling. After multimodal imaging studies, the patient underwent diagnostic orbital biopsy. The pathologic analysis of the biopsy showed a plasmacytic in…

Extranodal Rosai-Dorfman Disease A 28-year-old male without past medical history presented with a 1 year history of painless bilateral upper lid swelling. After multimodal imaging studies, the patient underwent diagnostic orbital biopsy. The pathologic analysis of the biopsy showed a plasmacytic in…

Severe Non-Proliferative Diabetic Retinopathy with Cystoid Macular Edema A 65-year-old male with diabetic retinopathy and CME presented to the BPEI retina clinic for continued management of his chronic ocular condition. His care was complicated by an inability to submit to ocular examinations in th…

Severe Non-Proliferative Diabetic Retinopathy with Cystoid Macular Edema A 65-year-old male with diabetic retinopathy and CME presented to the BPEI retina clinic for continued management of his chronic ocular condition. His care was complicated by an inability to submit to ocular examinations in th…

Central Serous Retinopathy A 48-year-old female presents with a history of chronically decreased vision in her right eye. Multimodal imaging reveals serous macular detachment, thickened choroid, and focal areas of late leakage on fluorescein angiography. The left eye has pigmentary changes in the p…

Central Serous Retinopathy A 48-year-old female presents with a history of chronically decreased vision in her right eye. Multimodal imaging reveals serous macular detachment, thickened choroid, and focal areas of late leakage on fluorescein angiography. The left eye has pigmentary changes in the p…

Ocular Ischemic Syndrome Ocular ischemic syndrome (OIS) is a rare condition associated with severe carotid artery occlusive disease leading to ocular hypoperfusion. It typically presents at mean age of 65, there is no racial predilection, and is two times more common in men than women. It is typica…