Cytomegalovirus Anterior Uveitis

A patient presented with acute blurry vision, foreign-body sensation, and elevated intraocular pressure in the left eye. On examination, he had evidence of chronic intraocular inflammation including keratic precipitates, He had experienced similar episodes periodically over the last two decades. Anterior chamber paracentesis was performed, and PCR analysis was positive for cytomegalovirus (CMV) DNA. The patient was treated with prednisolone acetate drops to reduce intraocular inflammation, dorzolamide-timolol drops to reduce intraocular pressure, and three-week course of oral valganciclovir for treatment of CMV infection. At most recent follow up, the patient’s clinical examination had improved with decreased anterior chamber inflammation and normalized intraocular pressure, and he had symptomatically improved as well. This case demonstrates clinical signs and symptoms of CMV-associated anterior uveitis and how identification of CMV DNA with anterior chamber paracentesis can change management by addition of antiviral drugs.

Presentation Date: 08/25/2022

Issue Date: 09/02/2022