Bilateral Retinoblastoma
A 7-month-old girl with a white pupil in the right eye is diagnosed with group D retinoblastoma in the right eye and group B retinoblastoma in the left eye. Her right eye is treated with intra-arterial chemotherapy with melphalan, carboplatin, and topotecan. Her left eye was treated with laser photocoagulation. Both eyes achieved tumor regression and were stable after 3 years of follow up. Genetic testing revealed a variant mutation of the RB1 gene, consistent with a hereditary pattern of mosaicism. Her twin sister did not show any signs of disease and had negative genetic testing.
Presentation Date: 04/23/2020
Issue Date: 08/01/2020
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Include in Catalogue?: No
Presenter(s): Jose J. Echegaray, MD
Faculty Discussant(s): J. William Harbour, MD