Carcinoma Consist with Metastasis and Lung Primary

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    Abstract

    A patient with a history of metastatic lung carcinoma involving the CNS and a previous mycobacterial infection presented for a routine evaluation, reporting decreased vision and worsening floaters in her right eye over the past two months. Two months before presentation, she arrived at the emergency department with a complaint of one week of dysarthria and feeling off-balance with unsteady gait as well as a 3-week history of bilateral floaters. After extensive imaging, metastatic disease from the lung was suspected, warranting a bronchoscopy with biopsy, leading to a diagnosis of lung adenocarcinoma. The patient has completed ten cycles of brain radiation therapy and is now set to begin chemotherapy. A diagnostic vitrectomy revealed atypical epithelial cells with foci present in clumped areas. Prominent nucleoli are present. The tumor stains positive for cytokeratin and TTF-1. The SOX10 stain is negative.

     

    Presentation Date: 05/15/2025

    Issue Date: 04/17/2026

     
  • Select activity Presenter: Miguel E. Hernandez, MD

    

    Presenter: Miguel E. Hernandez, MD URL
  • Select activity Faculty Discussant: Maura Di Nicola, MD

    

    Faculty Discussant: Maura Di Nicola, MD URL
  • Select activity Faculty Discussant: Sander R. Dubovy, MD

    

    Faculty Discussant: Sander R. Dubovy, MD URL
  • Select activity Faculty Discussant: Basil Williams, MD

    

    Faculty Discussant: Basil Williams, MD URL