Conjunctival Amyloidosis

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  A patient presented with a raised, well-demarcated, yellow-ish lesion of the left lower palpebral conjunctiva, which had been present for 2 months. The lesion had previously been treated as a chalazion without improvement. She had no systemic systems. Anterior segment OCT demonstrated a thickened, hyperreflective sub-epithelial lesion and pathology from biopsy showed deposition of amorphous eosinophilic PAS- and Congo Red-positive material demonstrating apple-green birefringence, consistent with amyloidosis. The patient was referred to hematology-oncology for systemic workup which is pending.
  

  Presentation Date: 12/18/2025
  Issue Date: 03/20/2026
  

  • Select activity Presenter: Kai R. Seely, MD, MHSc

    

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  • Select activity Faculty Discussant: Sander R. Dubovy, MD

    

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  • Select activity Faculty Discussant: Brian C. Tse, MD

    

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